Direct delivery of NO to the penis could potentially circumvent this limitation. Patients undergoing radical prostatectomy (RP) suffer from erectile dysfunction (ED) refractory to phosphodiesterase 5 inhibitors, which act downstream of cavernous nerve (CN)-mediated release of nitric oxide (NO). Tar, Moses Cabrales, Pedro Navati, Mahantesh Adler, Brandon Nacharaju, Parimala Friedman, Adam J Friedman, Joel Davies, Kelvin P Topically applied NO-releasing nanoparticles can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy. In both solvent systems, the stability of the resulting complexes was found to vary in the order Rb(+)>K(+) approximately Ba(2+)>Tl(+)>Cs(+)>NH(4)(+) approximately Pb(2+)>Ag(+)>UO(2)(2+)>Hg(2+)>Mg(2+)>Na(+). All the resulting 1:1 complexes in nitromethane- dimethylsulfoxide were more stable than those in acetonitrile- dimethylsulfoxide solution. A competitive (133)Cs NMR technique was also employed to probe the complexation of Na(+), K(+), Rb(+), Ag(+), Tl(+), NH(4)(+), Mg(2+), Ba(2+), Hg(2+), Pb(2+) and UO(2)(2+) ions with DB21C7 in the same solvent systems.
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(133)Cs NMR spectroscopy was used to determine the stoichiometry and stability of the Cs(+) ion complex with dibenzo-21-crown-7 (DB21C7) in acetonitrile- dimethylsulfoxide (96.5:3.5, w/w) and nitromethane- dimethylsulfoxide (96.5:3.5, w/w) mixtures. Sahmsipur, Mojtaba Dastjerdi, Leila Shafiee Alizadeh, Nader Bijanzadeh, Hamid Reza Topical DMSO is an effective and safe antidote that may be used with local cooling after extravasations of vesicant drugs other than those drugs for which standard interventions are defined.Ĭompetitive cesium-133 NMR spectroscopic study of complexation of different metal ions with dibenzo-21-crown-7 in acetonitrile- dimethylsulfoxide and nitromethane- dimethylsulfoxide mixtures. The treatment was well tolerated, with mild local burning and a characteristic breath odor being the only side effects of DMSO application, even in cases in which treatment continued for up to 6 weeks to obtain remission of the symptoms of extravasation.
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One hundred forty-four patients with extravasations of doxorubicin (n = 11), epirubicin (n = 46), mitomycin (n = 5), mitoxantrone (n = 13), cisplatin (n = 44), carboplatin (n = 6), ifosfamide (n = 14), and fluorouracil (n = 5) entered the study 127 were assessable. Intermittent local cooling (for 1 hour three times daily) on the first 3 days was also used.
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From June 1991 to December 1994, all patients who had an extravasation during intravenous (IV) infusion of cytotoxic drugs in our institution were considered for an open, prospective study of preventive treatment with 99% DMSO, applied topically on the extravasation site every 8 hours for 7 days. To evaluate the activity and tolerability of dimethylsulfoxide (DMSO) in the prevention of soft tissue toxicity after extravasation of cytotoxic drugs. Topical dimethylsulfoxide for the prevention of soft tissue injury after extravasation of vesicant cytotoxic drugs: a prospective clinical study.īertelli, G Gozza, A Forno, G B Vidili, M G Silvestro, S Venturini, M Del Mastro, L Garrone, O Rosso, R Dini, D